Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the ROR knockout
نویسندگان
چکیده
Monica I. Masana, Isabel C. Sumaya, Michael Becker-Andre, and Margarita L. Dubocovich Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Glaxo Institute for Molecular Biology, Geneva, Switzerland; Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine and Center for Drug Discovery and Chemical Biology, Northwestern University, Chicago, Illinois
منابع مشابه
Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout.
This study reports for the first time the effects of retinoid-related orphan receptors [RORbeta; receptor gene deletion RORbeta(C3H)(-/-)] in C3H/HeN mice on behavioral and circadian phenotypes. Pineal melatonin levels showed a robust diurnal rhythm with high levels at night in wild-type (+/+), heterozygous (+/-), and knockout (-/-) mice. The RORbeta(C3H)(-/-) mice displayed motor ("duck gait,"...
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تاریخ انتشار 2007